After the release of Jake Blues from prison, he and brother Elwood go to visit the orphanage where they were raised by nuns. They learn that the Church stopped its support and will sell the place to the education authority, and the only way to keep the place open is if the tax on the property is paid within 11 days. The brothers want to help, and decide to raise money by putting their blues band back together and staging a big gig. They may be on a mission from God, but they‘re making enemies everywhere they go.