The soundtrack of the computer and video game Grand Theft Auto: San Andreas, which is set in 1992 in the fictional U.S. West Coast state of San Andreas, required that the game's radio stations reflect the music tastes of the time and area, in addition to covering current events in the state of San Andreas, and even weather forecasts. Together with several pieces of early-1990s music, the soundtrack also included songs from the 1950s, 1960s, 1970s and 1980s. Many of the songs interpolate or sample other songs which feature in this or other GTA titles, such as Ice Cube's "Check Yo Self", which samples "The Message", which was featured in Vice City or "Weekend" which appears in its original form on Paradise FM in Grand Theft Auto: Vice City Stories.

Primarily, the player can hear the radio when the protagonist acquires a vehicle. The station that will be playing when the player gets in is determined by several factors, and players can change it or switch it off as desired. The only vehicles in which you cannot access the radio are the emergency and police vehicles, tractors, bicycles and certain boats. Radio stations, or some of the songs featured on them, can also be heard in the background in certain locations, such as bars, clothing stores, clubs, casinos, and safehouse wardrobes. The Xbox and PC versions of the game allow the player to create their own custom radio stations with user imported tracks. However, unlike previous GTA titles, which also offered this feature, San Andreas can place commercials between tracks.

The official soundtrack, available on Interscope Records, Grand Theft Auto: San Andreas Official Soundtrack and the Grand Theft Auto: San Andreas Official Soundtrack Box Set collection were released internationally on 23 November 2004 and 7 December 2004 respectively.