X-Men: The Last Stand is the third theatrical film adaptation of the Marvel Comics' X-Men superhero comic books, following X-Men and X2. Brett Ratner directed, having taken over when Bryan Singer dropped out to direct Superman Returns. The movie revolves around a "mutant cure" that causes serious repercussions among mutants and humans, and on the mysterious resurrection of Jean Grey, who appeared to have died in X2. The film is loosely based on two X-Men comic book story arcs: writer Chris Claremont's and artist John Byrne's "Dark Phoenix Saga" in The Uncanny X-Men and writer Joss Whedon's and artist John Cassaday's six-issue "Gifted" arc in Astonishing X-Men.

The film was released May 26, 2006 in the United States and Canada, and one or two days earlier in approximately 22 other countries. Despite mixed reviews from critics, the film did well at the box office. Its opening-day gross of $45.5 million is the fourth-highest on record while its opening weekend gross of $103 million is the fifth highest ever.

It has been several months since The X-Men stopped William Stryker, but that victory came at a price, they have lost Jean Gray when she tried to save them from the collapsed reservoir. Scott Summers (Cyclops) is still grieving about her loss. One day, he came out to the place which is where Jean Gray sacrificed herself. Then, Jean Gray appeared right in front of him. Though, it seemed that after that, Scott had disappeared. Meanwhille, the rift between humans and mutants had finally reached the boiling point. When humans discovered what causes humans to mutate, they have found a cure for the mutation. The X-Men were appalled at this idea. It was not long at all until the news about the cure came to Magneto. He decides to organize an army of mutants and wage his war against the humans. Then, it became clear that Jean Gray evolved into the Pheonix, her new mutant powers are so strong that she can not control her own body. Then, she kills off Professor X with her new powers. Now, The X-Men must stop Magneto again and put an end to the war against the humans, as well as stop Jean Gray's Pheonix powers. Written by John Wiggins

When a cure is created, which apparently can turn any mutant into a normal human being, there is outrage amongst the mutant community. Whilst some mutants do like the idea of a cure, including Rogue (Paquin), many mutants find that there shouldn't be a cure. Magneto (McKellen), who still believes a war is coming, recruits a large team of mutants to take down Warren Worthington II (Murphy) and his cure. Might seem easy for the X-Men to stop, but Magneto has a big advantage, which Wolverine (Jackman) doesn't have. Jean Grey (Janssen) has returned, and joined with Magneto. The Phoenix has woken within her, which has the ability to destroy anything in here past, even if that 'anything' is a X-Men. Written by Film_Fan

The X-Men, mutant heroes sworn to defend a world that hates and fears them, are back! This time, with the help of new recruits The Beast and Angel, they must face evolution itself in the form of their former teammate, Jean Grey. Possessed with the cosmic power of the Dark Phoenix, the resurrected Jean Grey has become a danger to herself, her mutant comrades, and the entire planet. To stave off this imminent threat to humanity, a potential cure is discovered and processed to treat -- and ultimately eliminate -- genetic mutations, once and for all. Now, as the battle lines are drawn, the X-Men, led by Professor Charles Xavier, must contend with both Jean Grey's world-consuming powers, as well as the malevolent Brotherhood, a band of powerful mutants organized under Xavier's former ally, Magneto. Written by comicfan

Mutants are on the verge of X-tinction, it seems, when US business Worthington Industries discovers a cure for mutation. This scientific breakthrough complicates and intensifies the battle - both physical and ideological - between Professor X's integration-friendly X-Men and the human-hating muties let by Magneto ... Written by comicfan

When a private laboratory supported by the government finds the cure for the mutants, using the DNA of a powerful boy, the mutants have the option of giving up their powers and become human, but their society split. Magneto opposes and decides to join a force to fight against the government and kill the mutant boy. Meanwhile, Jean Grey resurrects uncontrolled by Xavier and with the personality of the powerful Dark Phoenix. She destroys Cyclops and Professor Charles Xavier, and allies to the evil forces of Magneto, making them almost invincible. Written by Claudio Carvalho, Rio de Janeiro, Brazil