Wilfredo Jose Ledezma (born January 21, 1981 in Guárico State, Venezuela) is a pitcher in Major League Baseball who plays for the San Diego Padres. He bats and throws left-handed.

As of the end of the 2005 season, Ledezma has compiled a Major League record of 9-14 with 108 strikeouts and a 5.73 ERA in 187.0 innings. Most of his professional career thus far has been spent in the minor leagues.

Ledezma was originally signed by the Boston Red Sox in 1998. He was taken by the Tigers in the 2002 Rule 5 draft.