Wayne General Simmons (December 15, 1969 - August 23, 2002) was a former American football linebacker in the National Football League. Simmons was drafted by the Green Bay Packers with the 15th pick of the first round of the 1993 NFL Draft. Simmons played for Green Bay for four and a half years, earning a Super Bowl ring in 1996. Simmons was well known for shutting down opponents tight ends, but in doing this task extremely well he was not able to obtain the attention drawing statistics such as quarterback sacks. Simmons was traded to the Kansas City Chiefs during the 1997 season when Seth Joyner returned from knee surgery. The Chiefs waived Simmons in 1998 after a 30-7 Monday Night loss to arch-rival Denver Broncos, in which Simmons and fellow linebacker Derrick Thomas were called for a total of five personal fouls on the Broncos' final touchdown drive. The Buffalo Bills claimed Simmons off waivers on November 19, 1998 and played five games. He was released by the team in February of 1999.

In college, Simmons was an integral part of Clemson's #1 ranked defense in 1990.