William Sterling Cole (April 18, 1904 - March 15, 1987) was a Republican member of the United States House of Representatives from New York.

Cole was born in Painted Post, New York. He graduated from Colgate University in 1925 and Albany Law School in 1929. He was elected to Congress in 1934 and served from January 3, 1935 until his resignation on December 1, 1957. He resigned to become the first Director General of the International Atomic Energy Agency and remained at that post until 1961. He died in Washington, D.C..