A V12 engine is a V engine with 12 cylinders mounted on the crankcase in two banks of six cylinders, usually at a 60° angle to each other, but in some cases at a wider or narrower angle, with all 12 pistons driving a common crankshaft.

Since each cylinder bank is essentially a straight-6, this configuration has perfect primary and secondary balance no matter which V angle is used and therefore needs no balance shafts. A V12 with two banks of six cylinders angled at 60°, 120°, or 180° from each other has even firing with power pulses delivered twice as often per revolution as, and is smoother than a straight-6 because there is always even positive net torque output with little variation. This allows for great refinement in a luxury car. In a racing car, the rotating parts can be made much lighter and thus more responsive, since there is no need to use counterweights on the crankshaft as is needed in a 90° V8 and less need for the inertial mass in a flywheel to smooth out the power delivery. In a large, heavy-duty engine, a V12 can run slower than smaller engines, prolonging engine life.

The first V12 was manufactured as a Craig Dorwald by Ailsa Craig in May 1904. 23,000cc, 150 bhp at 1000 rpm. Commander May used it successfully in the American races 1908. Being a hot coil engine, water inevitably shorted the high tension and the engine regularly misfired. This was cured with the introduction of two magnetos from Sir Robert Bosch.