The University of Chicago Press is the largest university press in the United States. It is operated by the University of Chicago and publishes a wide variety of academic titles, including The Chicago Manual of Style, dozens of academic journals, including Critical Inquiry, and a wide array of advanced monographs in diverse academic fields.

One of its quasi-independent projects is the BiblioVault, a digital repository for scholarly books.

The Press building is located just south of the Midway Plaisance on the University of Chicago campus.