The United States Department of State, often referred to as the State Department, is the Cabinet-level foreign affairs agency of the United States government, equivalent to foreign ministries in other countries. It is administered by the Secretary of State.

It is headquartered in the Harry S Truman Building at 2201 C Street, N.W., a few blocks from the White House in the Foggy Bottom neighborhood of Washington, D.C. The Department's Secretary is the first Cabinet member in the line of succession in the event of the disability or death of the President, and is fourth after the Vice President, the Speaker of the House, and the President pro tempore of the United States Senate.