Tsuzuki-ku is one of the 18 wards of the city of Yokohama in Kanagawa Prefecture, Japan. As of 2003, 171,429 people lived in Tsuzuki-ku. Tsuzuki-ku is 27.88 km² in area. Its average age of 36.0 makes this the youngest ward in Yokohama. Tsuzuki-ku is also the newest ward in the Yokohama. The 1994 merger of parts of Midori-ku and Aoba-ku formed Tsuzuki-ku.

The tree of Tsuzuki-ku is crape myrtle and lots of crape myrtle grow in the ward. The Yokohama Historical Museum in Tsuzuki-ku was built in January 1995. A big hospital was built in 2003, and this hospital is one of the biggest in Tsuzuki-ku.