The Killing of Sister George is a 1964 play by Frank Marcus that served as the basis for a 1968 film directed by Robert Aldrich.

Sister George is a beloved character in the popular radio series Applehurst, a nurse who ministers to the medical needs and personal problems of the local villagers. She is portrayed by June Buckridge, who in real life is a gin-guzzling, cigar-chomping, slightly sadistic lesbian, the antithesis of the sweet character she plays. June lives with Alice "Childie" McNaught, a considerably younger dim-witted woman she often verbally and sometimes physically abuses. When June discovers her character is scheduled to be killed, she becomes increasingly impossible to work and live with. Mercy Croft, an executive at the radio station, intercedes in her professional and personal lives supposedly to help, but she actually has an agenda of her own.

Although it is strongly implied that June and Childie are lesbians, and towards the end we discover that Mercy could be as well, this is never explicitly stated. Marcus intended the play to be a farce, not a serious treatment of lesbianism, but because there was so little material about lesbians it became treated as such. It was also to some extent a parody of the killing of Grace Archer in The Archers.

The 1964 West End production starred Beryl Reid as June. Two years later she reprised the role on Broadway in a production directed by Val May. After 7 previews, it opened on October 5, 1966 at the Belasco Theatre and ran for 205 performances. The cast also included Eileen Atkins as Alice and Lally Bowers as Mercy. Beryl Reid won the Tony Award for Best Actress in a Play and the play and Eileen Atkins received nominations.

George lives with her lover, Childie and plays a cheerful district nurse in a BBC soap opera. However, her character is to be killed off, and George realises that the only other job she can get is the voice of a cow in a children's tv programme. Her life begins to fall apart as Childie has an affair with a predatory tv producer. Written by Paul Baker

"Sister George" is a BBC soap opera character who is "killed off" due to low ratings. The aging actress who portrays Sister George is a lesbian living with a childish middle-aged woman named Childie, who works in a factory when not playing with her doll collection. Conflict arises between the two lovers when the hard-nosed BBC female program director, who told George of her canceled part, also steals Childie away. As consolation for losing both her job and her lover, George is offered the voice part of a puppet cow in a new animated cartoon series. Written by alfiehitchie