The Assassination of Jesse James by the Coward Robert Ford is a 2007 Academy Award nominated Western drama film adapted from Ron Hansen's 1983 novel of the same name. The film is directed by Andrew Dominik, with Brad Pitt portraying Jesse James and Casey Affleck as Robert Ford. Filming took place in Calgary, Edmonton and Winnipeg. Initially intended for a 2006 release, the film was postponed and re-edited for a September 21, 2007 release. While the film contains representations of historical figures, it notably dramatizes the relationship between James and Ford.

When casting for the role of Robert Ford it came down to Casey Affleck and Shia LaBeouf. Affleck eventually got the role, because LaBeouf was felt to be too young.

Garret Dillahunt was originally set to play Casey Affleck's brother, due to their striking resemblance, but due to a TV commitment, Dillahunt was given a smaller role and Sam Rockwell replaced his original part.

According to Andrew Dominik, Brad Pitt had it put in his contract that the name of the movie was not to be changed.