The 50 Greatest Game Shows of All-Time was a series on GSN airing from July 18 2006 through August 31 2006, on Tuesdays, Wednesdays, and Thursdays at 10 PM Eastern Time. Hosted by Bil Dwyer, the series counted down the 50 greatest American game shows of all time as chosen by GSN executives, who voted on the best game shows from a list of programs nationally broadcast in the United States since the 1940s.

Episodes airing in the countdown usually were rarely seen, classic or notable episodes of those shows of which episodes still exist, and which GSN had the rights to air. Two shows GSN programmed at the time of their presentation in the countdown—Beat the Clock and Jeopardy!—were not represented by an episode, while an episode of Shop 'til You Drop was featured, even though the program had never appeared on GSN before.

Each installment of the countdown featured either a single episode of an hour-long game show, or two half-hour episodes. Starting with number eight on the list, half-hour shows took the whole hour with two episodes. Shows that were not represented with actual airings of episodes were instead featured during the bumpers in the countdown, which displayed still production photographs of these series as Dwyer described them and their prominence.

GSN repeated this list starting May 5, 2007 on a once-a-week basis normally presented in two-hour installment episode blocks on Saturday nights, and ended as scheduled after eleven weeks on July 14, 2007.