Syracuse (locally ˈsɛrəkjuːs, sometimes or /ˈsɪərəkjuːs/ by non-natives) is a city in Central New York, USA. According to the 2000 census, the city population was 147,306, and its metropolitan area had a population of 732,117. It is the county seat of Onondaga County and the economic and educational hub of Central New York, a region with over a million inhabitants. Syracuse is also well provided with convention sites, with a downtown convention complex and the Empire Expo Center directly west of the city, which hosts the annual Great New York State Fair. Syracuse was named after the original Syracuse, a city on the eastern coast of Sicily, Italy, most famously noted in the Bible, Acts 28:12, with which it shares some similarities, including a formerly important salt industry and a neighboring town of Salina.

The city has functioned as a major crossroads over the last two centuries, first between the Erie Canal and its branch canals, then of the railway network. Today, Syracuse is located by the intersection of Interstates 90 and 81, and its airport is the largest in the region.

Syracuse is home to Syracuse University, a major research university, as well as several smaller colleges and professional schools.