The Spanish missions in California comprise a series of religious outposts established by Spanish Catholics of the Franciscan Order between 1769 and 1823 to spread the Catholic faith among the local Native Americans. The missions represented the first major effort by Europeans to colonize the Pacific Coast region, and gave Spain a valuable toehold in the frontier land. The settlers introduced European livestock, fruits, vegetables, and industry into the California region; however, the Spanish occupation of California also brought with it serious negative consequences to the Native American populations with whom the missionaries came in contact. Today, the missions are among the state's oldest structures and the most-visited historic monuments.