South Park, Colorado is the fictional town that is the setting of the animated television series of the same name, created by Trey Parker and Matt Stone. The town is located in South Park, a geographical area of approximately 1000 square miles which is a sparsely treed, high-altitude intermontane grassland basin. South Park is in Park County about 80 miles southwest of Denver. An unexplained peculiarity is that it is almost always winter in South Park, and there is (almost) always snow on the ground. This could be because the appearance of the characters, which were first introduced in a Christmas short, were dressed for winter.

South Park is inspired by both real-life towns in the South Park basin such as Fairplay and the Denver suburbs such as Littleton, the sites of the upbringing of South Park co-creators Matt Stone and Trey Parker. The town is served by South Park Elementary and Hell's Pass Hospital. Town police consists almost entirely of Officer Barbrady (not counting county sheriff's deputies Yates and Murphy) and the only discernible politician is Mayor McDaniels. The town flag was changed in Chef Goes Nanners because the image of white people lynching a black man was thought racist. The new flag features a black man being lynched by people of all races and nationalities, including another black man. South Park was home to Jesus until his death in Red Sleigh Down; however, since he is resurrected in Fantastic Easter Special, it is unknown if he still lives in South Park.