The Serengeti ecosystem is located in north-western Tanzania and extends to south-western Kenya between latitudes 1 and 3 S and longitudes 34 and 36 E. It spans some 30,000 km.

The Serengeti hosts the largest and longest overland migration in the world, a semi-annual occurrence. This migration is one of the seven tourist travel wonders of the world.

The region contains several national parks and game reserves. Serengeti is derived from the Maasai language, Maa; specifically "Serengit", meaning "Endless Plains".

Approximately 70 larger mammal and some 500 avifauna species are found there. This high diversity in terms of species is a function of diverse habitats ranging from riverine forests, swamps, kopjes, grasslands and woodlands. Blue Wildebeests, gazelles, zebras and buffalos are some of the commonly found large mammals in the region.

Around October, nearly 2 million herbivores travel from the northern hills toward the southern plains, crossing the Mara River, in pursuit of the rains. In April, they then return to the north through the west, once again crossing the Mara River. This phenomenon is sometimes called the Circular Migration. Over 250,000 wildebeest alone will die along the journey from Tanzania to Masai Mara Reserve in upper Kenya, a total of 500 miles. Death is often caused by injury, exhaustion, or predation. The migration is chronicled in the 1994 documentary film, Africa: The Serengeti.