The Secretary of the Senate, an elected officer of the United States Senate, supervises an extensive array of offices and services to expedite the day-to-day operations of that body. The office is somewhat analogous to that of the Clerk of the U.S. House of Representatives.

The first secretary was chosen on April 8, 1789, two days after the Senate achieved its first quorum for business. From the start, the secretary was responsible for keeping the minutes and records of the Senate, including the records of senators' election, and for receiving and transmitting official messages to and from the president and the House of Representatives, as well as for purchasing supplies. As the Senate grew to become a major national institution, numerous other duties were assigned to the secretary, whose jurisdiction now encompasses clerks, curators, and computers; disbursement of payrolls; acquisition of stationery supplies; education of the Senate pages; and the maintenance of public records. Today, the secretary coordinates two of the largest technology initiatives in Senate history, both designed to bring state-of-the-art efficiency to management of legislative and financial information. The secretary's responsibilities include both legislative and administrative functions. Today, by agreement of the two parties, the Majority Leader "appoints" the Secretary of the Senate, and the election is merely ceremonial.

The current secretary (for the 110th Congress) is Nancy Erickson.