Perfect 10 was a quarterly men's magazine featuring high resolution photographs of topless or nude women who have not had cosmetic surgery, and focused in particular on slender models with piercing eyes and medium to large, youthful breasts in pensive or artistic poses. A recurring theme was that of the model wearing boxing gloves. To this end Perfect 10 had even gone so far as to promote and film boxing matches between a number of their models, aired most recently as Perfect 10: Model Boxing on the Showtime and HD.net cable channels.

The majority of Perfect 10 's models hailed from Eastern Europe--particularly former Soviet Union states--although many American and Brazilian models were also showcased. Perfect 10 was often the first to feature upcoming fashion models and glamour models nude, and a number have gone on to become Playboy Playmates or Penthouse Pets, most notably Jodi Paterson (2000 Playboy Playmate of the Year) and Erica Lookadoo (aka Juliet Cariaga, 2000 Penthouse Pet of the Year). Lexie Karlsen posed in Perfect 10, then became both a Playboy Playmate and Penthouse Pet. Miss Universe contestants Evelina Papantoniou (Miss Greece 2001) and Leilani Dowding (Miss Great Britain 1998) also posed for the magazine. Other notable Perfect 10 models included Erica Campbell, Katie Richmond, Veronika Zemanová, Marisa Miller, Tereza Benesova, and Ashley Degenford. Many Page 3 girls have appeared in the magazine's pages, like Michelle Marsh and Sophie Howard.

In keeping with the natural beauty aspect of the publication, the models used less make-up than is typical for the industry.