Panama City (Ciudad de Panamá) is the capital and largest city of the Republic of Panama. It has a population of 708,738, with a total metro population of 1,063,000, and it is located at the Pacific entrance of the Panama Canal, at . Panama City is the political and administrative center of the country. Juan Carlos Navarro is Panama City's current mayor.

Panama City has been for 7 years in the top 5 places for retirement in the world according to International Living Magazine

Panama City has a dense skyline, including mostly apartment buildings, but office complexes and hotels as well. Panama City is an important hub for international banking and commerce. It has an advanced communications service, Internet use is widespread; and Panama City's Tocumen International Airport offers daily flights to international destinations.

Panama City was chosen to be the American Capital of Culture for the year 2003 (jointly, with Curitiba, Brazil).