Natural Born Killers is the soundtrack to the film Natural Born Killers, produced by Trent Reznor of Nine Inch Nails. Reznor reportedly produced the soundtrack using a portable Pro Tools in his hotel room while on tour. On his approach to compiling the soundtrack, Reznor told MTV:

I suggested to Oliver [Stone] to try to turn the soundtrack into a collage-of-sound, kind of the way the movie used music: make edits, add dialog, and make it something interesting, rather than a bunch of previously released music.

Some songs were written especially for the film or soundtrack, such as "Burn" by Nine Inch Nails, and "What Would You Do" by Tha Dogg Pound.