IntelliMouse® is a brand name by Microsoft for its line of computer mice. The IntelliMouse series is credited with a number of important innovations in the computer mouse field. For example, Microsoft was among the first mouse vendors to introduce a scroll wheel, an optical mouse, and dedicated forward and back buttons on the side of the mouse for easier web browsing. Microsoft has also introduced one of the first mainstream ergonomic mice, the Microsoft Natural Wireless Laser Mouse 6000. This mouse features an unusual design in which the user's hand is tilted at an angle to reduce compression of the nerves in the wrist (unlike conventional mice, which have the user's palm facing down).

The current IntelliMouse lineup includes a broad variety of models, both wired and wireless. Its main competitor is Logitech.