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The Michigan-Ohio State rivalry (known to many fans of the teams as simply The Game) is the intense rivalry between the University of Michigan and The Ohio State University football teams. It has attracted particular national interest over the last four decades as most of the games have determined the Big Ten Conference title and the resulting Rose Bowl match ups, and many have influenced the outcome of the national collegiate football championship. The game was ranked by ESPN in 2000 as the greatest North American sports rivalry.

The annual matchup between the two Midwest state schools has been held at the end of the regular season since 1935. In 1942 both schools played one more regular season game the week after their matchup in Columbus. Michigan played Iowa at home and Ohio State hosted Iowa Navy Pre-Flight. In 1986 and 1998 Michigan concluded their regular season with trips to Honolulu to play Hawaii. Since 1918, the game's site has alternated between Columbus, Ohio, and Ann Arbor, Michigan, and has been played in Ohio Stadium since 1922 and Michigan Stadium since 1927.

During 1835-36, the State of Ohio and the Michigan Territory engaged in a brief and bloodless border dispute known as the Toledo War. Some have proposed that the football rivalry is a modern manifestation of this historical tension.