Merillon Avenue is a train station on the Main Line (Port Jefferson Branch service) of the Long Island Rail Road. It is located at Nassau Boulevard and Merillon Avenue in Garden City. The station is wheelchair accessible with two side platforms and a crossunder at Nassau Boulevard. It is located right next to a 7-Eleven store.

The Merillon Avenue station is known as being the final stop on the 5:33 train from Penn Station to Hicksville on December 7, 1993, when Colin Ferguson opened gunfire at passengers who were white. Six people died and 19 others were wounded. Carolyn McCarthy, whose husband was killed and her son seriously injured in the tragedy, pressed for tougher gun control laws and was elected to the United States House of Representatives in 1996. There is a memorial wreath at the station. See Long Island Rail Road massacre.