Melissa Duck is a fictional character featured on the animated television series Baby Looney Tunes, voiced by Janyse Jaud. Melissa is a comedian and enjoys making her friends laugh. However, her humor sometimes gets her in trouble when she crosses the line. She is featured in Looney Tunes and voiced by originally Bea Benaderet and later Grey DeLisle and she is voiced by Janyse Jaud for Baby Looney Tunes.

The premise of Baby Looney Tunes is to take adult characters from the original Looney Tunes theatrical shorts and cast them as infants. However, unlike well-known male characters such as Bugs Bunny and Daffy Duck, females characters were rare in the original shorts. Melissa Duck, Petunia Pig and Tasmanian She Devil only have a couple appearances each in the original films, while Lola Bunny was an original character created for the 1996 movie Space Jam.

Melissa Duck appeared in adult form in only two of the original Looney Tunes shorts — namely Chuck Jones's The Scarlet Pumpernickel (1950) and Robert McKimson's Muscle Tussle (1953). Her design is markedly different between the two films, but her appearance in The Scarlet Pumpernickel is the one upon which current images of the character are based. In both of these shorts, she was Daffy Duck's girlfriend, though in quite different contexts.

Melissa later had a starring role in the Greg Ford/Terry Lennon-directed The Duxorcist (1987), the first Looney Tunes short released to theaters after the original series ended in 1969. A loose parody of William Friedkin's The Exorcist, the film finds Melissa, here a single young urban woman, possessed by a trio of parasitic ghosts who cause her to periodically morph into a grotesque fanged creature (a reference to Linda Blair's demonic possession in the Friedkin film.) The task of banishing the spirits falls to ghost hunter Daffy Duck, who unfortunately is too smitten with his customer to focus on the task at hand. For most of the film, Melissa's personality jumps back and forth between her normal self, who returns Daffy's romantic interest, and her demonic self who keeps trying to roast him alive. At the end of the film, when the spirits have jumped out of her body (and into Daffy's) she inexplicably transforms into a Southern Belle type. Melissa was also apparently the inspiration for the Shirley the Loon character on Tiny Toon Adventures. They are similar-looking female waterfowls with a romantic interest in the male duck character — Daffy in Looney Tunes, Plucky Duck in Tiny Toons.