Me Against the World is a hip hop album by Tupac Shakur, released on March 14 1995 (see 1995 in music). The album was recorded before and while Shakur was recovering from his November 1994 shooting, and released while he was incarcerated. Perhaps as a result of these circumstances, Me Against the World has become known to many as the most incendiary of Shakur's releases, expressing an intensely personal mix of emotions and reactions to the events of his life. The album consists of frequent digressions into the dangers of paranoia, organized crime, and the moral repercussions of violence. Although the album was originally released on Shakur's label Out Da Gutta Records, Amaru Entertainment, the label owned by Shakur's mother, has since gained the rights to it.

This album, has been credited as setting the "nothing to lose" persona adopted by many rappers since Shakur's death. The album is generally regarded as a classic album by the hip hop community due to its soulful and emotional content, claiming that Pac could make you feel as if you were in his shoes throughout the album, thus making the album distinct from others. In one particular review it was said that Tupac's uncovered and raw humanity created a flow of inspiration and vibes through all who heard the album, and that it is a remarkable and somewhat insightful musical achievement.

Me Against the World topped the Billboard 200. Shakur thus became the first artist to have an album debut at #1 while incarcerated. In a late-1995 interview with MTV, Shakur expressed amazement over the fact that Me Against the World held the top spot on the Billboard charts, over artists as mainstream as Bruce Springsteen. In a different interview with MTV's Tabitha Soren, taped after Shakur was bailed out of the Clinton Correctional Facility, the rapper described Me Against the World as his favorite album, up to that point. The album debuted at number-one and stayed there for five weeks with first week sales of over 455,000 copies which, at the time, was the record for longest time at the top of the charts for a solo male rap artist. Many fans consider Me Against the World to be Shakur's best album, the album has also garnered significant critical acclaim, earning a perfect 5 Star rating from The Source and All Music Guide and went on to sell over 3 million copies in the U.S.