"Manic Depression" is a song written and recorded by Jimi Hendrix and released in 1967 on the Are You Experienced? album.

The song's name, "Manic Depression", is an old name for bipolar disorder, a mental health disorder. There is no evidence the Hendrix ever suffered from bipolar disorder himself. Jimi was doing a press conference in London and his manager at the time Chas Chandler told him that he sounded like a manic depressive. So the next day Hendrix wrote this tune.

Musically, the tune is a rare thing: a hard rock waltz. The lack of equilibrium inherent in the 3/4 meter, and when played in such a hard driving style, is appropriate for the subject matter of the song. Its style also owes a lot to blues and jazz influences.

"Manic Depression" has been covered by the Red Hot Chili Peppers; Styx; Blood, Sweat and Tears; Carnivore; Nomeansno; David Ryan Harris; Seal & Jeff Beck; Clawfinger; Jan Hammer; Katharina Franck; King's X; Stevie Ray Vaughan; Yngwie J. Malmsteen; et al. The Hungarian Gypsy band Besh O Drom have a track called Mániás Depresszió on their album Gyi! which uses Hendrix's tune. Rozz Williams and Gitane Demone released a very different version of Manic Depression on their album Dream Home Heartache.

There is also a second, unrelated, song called "Manic Depression (Jimi)" by Ian Dury and the Blockheads on their album Laughter.