"Make Me Better" is the second single from Fabolous' album From Nothin' to Somethin'. The song features Ne-Yo and is produced by Timbaland. He quoted that "the beat is unique sounding and the strings are so good that they will have to be used on future songs". The strings are sampled from Sherine's Al Sa'ban Aleh. A similar sample was used by the RZA on Raekwon's 1995 track "Rainy Dayz". The track — which features Ne-Yo on the hook and was produced by Timbaland — finds Fab in a very familiar mode, talking to the ladies. As for the lyrics, Fab and Ne-Yo tell ladies they are forces to be reckoned with on their own — but with their ladies upgrading them, they're that much better. "You want a girl that completes you and makes you better," he explained. "You don't want a girl who brings more arguments and more bills. ... You want a girl who, when you're walking around with your tie crooked, she fixes your tie. .... That's the kind of [woman] I'm looking for. Whether she's a celebrity or non-celebrity don't really matter. You just need somebody you can connect with. "It touches so many places," Fab added of the song. "It's a sexy record, plus a swagger record, an anthem record all in one. ... I played it for a couple of dudes a week ago, and they was like, 'I'mma tell my shorty that: "Yo, shorty, you make me better. I'm cool, I'm fly and sh--, but us together, we make a great pair." "Dudes can take it — it's giving them some game. I felt it could work on all levels."

The full song was leaked to the internet on April 9.

A video was released on May 23, 2007. Roselyn Sánchez appears as Fabolous's love interest in the video.

On the issue date of June 9, 2007 the single debuted on the Billboard Hot 100 at number 96 and has thus far peaked at number 8. "Fabolous and Ne-Yo - Make Me Better global chart positions and trajectories". aCharts.us. Retrieved June 30 2007.

The single has spent 14 weeks at number 1 in the Billboard Hot 100 Rap Tracks. This is a record for 2006 and 2007 on this chart.