For the Evanescence song, see The Open Door

"Lose Control" is a 2005 single by Missy Elliott featuring Ciara and Fatman Scoop, released on Goldmind/Atlantic Records. It contains samples from Les Rythmes Digitales's Music Makes You Lose Control, Cybotron's "Clear" and Hot Streak's "Body Work". The first single from Elliott's sixth album The Cookbook (2005), "Lose Control" peaked at number-three on the Billboard Hot 100 in the United States, becoming Elliott's ninth top ten single, Ciara's fourth, and Fatman Scoop's first. "Lose Control" went platinum five times, becoming her biggest single to date (passing the previous single "Work It").

The music video features a cameo by Tommy Lee. The video also features Elliott in a desert, in a solid black room with other dancers, in an old wooden house and in a row of dancers, dancing by a car. The song is about her telling people to stop being wall flowers and start dancing.

"Lose Control" was the first single by Kevin Federline from his debut effort Playing with Fire. Federline closed the 2006 Teen Choice awards show on August 20 by performing his rap track, "Lose Control" after being introduced by Britney Spears, who was then his wife ("My man, Kevin Federline!").

As with his previous failed single PopoZão, "Lose Control" failed to reach any singles chart, though it did fare better than its predecessor.