Lois Griffin (nee. Pewterschmidt) is a fictional character from the animated television series Family Guy. She is the wife of Peter Griffin, and the mother of Meg, Chris, and Stewie. She is voiced by former MADtv cast member Alex Borstein.

For the Family Guy character, see Lois Griffin.

Lois Griffin was a Metro Toronto councillor (Rexdale-Thistletown) and became the Chair of the Toronto Transit Commission from 1989 to 1991. She was the first woman to hold the post.

She played a critical role in creating the Network 2011 plan, and the building of the Sheppard subway line.