"Little Sister" was the first single released by the rock group Queens of the Stone Age from their fourth album Lullabies to Paralyze. The song was recorded live in the studio in one take.
The song had been in the works for quite a while. An early version was recorded with Dave Grohl in 2002 for the album Songs for the Deaf, but was scrapped. The unfinished recording was later distributed on a bootleg recording compilation. According to Josh Homme, the song was inspired by the "sort of sexual twist" of Doc Pomus's song of the same name, which is probably best known as recorded by Elvis Presley.
When this song was performed on Saturday Night Live on May 14, 2005, actor/comedian Will Ferrell, who hosted the show, came onstage and played the cowbell as fictional Blue Öyster Cult member Gene Frenkle. This was a reprise of a role that Ferrell played in a famous 2000 sketch in which actor Christopher Walken demands, "More cowbell!" during the studio recording of that band's famous song, "(Don't Fear) The Reaper", much to the chagrin of the rest of the band.
It has also been featured in the video games Midnight Club 3: DUB Edition and Project Gotham Racing 3. Additionally, it appears in the music video game Rock Band as downloadable content individually or in a 3-song pack along with other Queens of the Stone Age songs, "3's and 7's" and "Sick, Sick, Sick".
