Leo and Me was a Canadian television sitcom that was originally produced in 1976 but did not air until 1981.

It starred a 15 year old Michael J. Fox, in his television acting debut, playing Jamie, the 12 year old younger brother of Leo (Brent Carver).

Leo and Me was produced by Don Eccleston, directed by Don S. Williams and written by Marc and Susan Strange.

Was not aired for two years.

Three other cast/crew members on the series, besides Michael J. Fox (I), were diagnosed with Parkinson's Disease. An investigation was lunched in 2002, where the disease was linked to a virus.