Lee Chamberlin (born February 14, 1938, in New York, New York, USA), is an American film and television actress. She was a regular performer during the first two years of the esteemed series The Electric Company, and she made guest appearances in the television series What's Happening!! Diff'rent Strokes, and NYPD Blue to list a few. She had a prominent role in the film Uptown Saturday Night, in which she portrayed the memorable Madame Zenobia. She also starred in the film Let's Do it Again, the follow-up film to Uptown Saturday Night.

From 1982 through 1991, Chamberlain portrayed Pat Baxter, the mother of the popular character Angela Baxter Hubbard on the ABC soap opera All My Children.