Karditsa (Greek: Καρδίτσα) is a city in western Thessaly in mainland Greece. The city of Karditsa is the capital of Karditsa Prefecture.

Inhabitation is attested from 9000 BCE. Karditsa ls linked with GR-30, the road to Karpenisi, and the road to Palamas and Larissa. Karditsa is south-west of Palamas and Larissa, west of Farsala and the Volos area, north-west of Athens, Lamia, Domokos and Sofades, north of Karpenisi, north-east of Arta, and east-south-east of Trikala, Grevena, Ioannina, and Kalampaka.

Karditsa has schools, lyceums, gymnasium, the Veterinary Medicine Department of the University of Thessaly, three technical education departments, church, banks, a post office, a railway station on the Trikala - Karditsa - Domokos line, a sports ground, a water tower, and squares (plateies). Karditsa is one of the most bicycle-friendly cities in Greece with an extensive network of bicycle paths. Approximately 30% of all the city transportation, according to the National Technical University of Athens, is done by bicycles.