The semi-fictionalized version of Jerry Seinfeld is the main protagonist on the United States television sitcom Seinfeld (1989-1998). The character was named after, based on, and played by the comedian himself.

The series revolves around Jerry's misadventures with his best friend George Costanza, wacky neighbor Cosmo Kramer, and ex-girlfriend Elaine Benes. He is usually the voice of reason amidst his friends' antics and the focal point of the foursome's relationship. An eternal optimist, he rarely runs into major personal problems. Jerry is the only main character on the show to maintain the same career (a stand-up comedian, like the real Seinfeld) throughout the series. He is the most observational character, sarcastically commenting on his friends' quirky habits.

Much of the show's action takes place in Jerry's apartment located at 129 West 81st Street, apartment 5A, as stated in the episode "The Alternate Side". He and his friends also frequently appear in "Monk's", a fictional cafe. The outside sign for Monk's that is shown before we see the inside scene is actually that of Tom's Restaurant, a diner style eatery located near Columbia University on Broadway.

Jerry appeared in all 180 episodes of Seinfeld (including several 2-part episodes), holding the distinction of being the only character in the show to appear in every episode.