The Jerry Lewis MDA Telethon is hosted by Jerry Lewis to raise money for the Muscular Dystrophy Association. It has been held annually since 1966. The telethon has raised $1.46 billion by 2007.

It is held on Labor Day weekend, starting on the Sunday evening preceding Labor Day and continuing until late Monday afternoon, syndicated to approximately 190 television stations throughout the United States. MDA calls its network of participating stations The Love Network. The Telethon has originated from Las Vegas for 23 of the 40 years it has aired.