Interstate 240 (abbreviated I-240) is an interstate highway in Oklahoma, USA, that runs 16.22 miles (26.1 km) west from Interstate 40 to Interstate 44 in southern Oklahoma City. After its terminus in southwest Oklahoma City, the main I-240 roadbed becomes Interstate 44 and Airport Road toward Will Rogers World Airport. The interstate overlaps OK-3, the longest Oklahoma state highway, for its entire length.

Major destinations along the route include Crossroads Mall, Tinker Air Force Base, and the heavily populated Southside of Oklahoma City.

I-240's service road is named S.E. 74th Street.