The Core 2 brand refers to a range of Intel's consumer 64-bit dual-core and MCM quad-core CPUs with the x86-64 instruction set, and based on the Intel Core microarchitecture, which derived from the 32-bit dual-core Yonah laptop processor. (Note: The Yonah had two interconnected cores, similar to those branded Pentium M, but comprising a single silicon chip or die.) The 2x2 MCM dual-die quad-core CPU had two separate dual-core dies (CPUs) - next to each other - in one quad-core MCM package. The Core 2 relegated the Pentium brand to a lower-end market, and reunified the laptop and desktop CPU lines that had been divided into the Pentium 4, D, and M brands.

The Core microarchitecture returned to lower clock speeds and improved processors' usage of both available clock cycles and power compared with preceding NetBurst of the Pentium 4/D-branded CPUs . It provides more efficient decoding stages, execution units, caches, and buses, reducing the power consumption of Core 2-branded CPUs, while increasing their processing capacity.

The Core 2 brand was introduced on July 27, 2006 comprising the Solo (single-core), Duo (dual-core), Quad (quad-core), and Extreme (dual- or quad-core CPUs for enthusiasts) branches, during 2007 .