Itanium is the brand name for 64-bit Intel microprocessors that implement the Intel Itanium architecture (formerly called IA-64). Intel has released two processor families using the brand: the original Itanium and the Itanium 2. Starting November 1, 2007, new members of the second family are again called Itanium. The processors are marketed for use in enterprise servers and high-performance computing systems. The architecture originated at Hewlett-Packard (HP) and was later developed by HP and Intel together.

Itanium's architecture differs dramatically from the x86 architectures (and the x86-64 extensions) used in other Intel processors. The architecture is based on explicit instruction-level parallelism, with the compiler making the decisions about which instructions to execute in parallel. This approach allows the processor to execute up to six instructions per clock cycle. By contrast with other superscalar architectures, Itanium does not have elaborate hardware to keep track of instruction dependencies during parallel execution - the compiler must keep track of these at build time instead.

After a protracted development process, the first Itanium was released in 2001, and more powerful Itanium processors have been released periodically. HP produces most Itanium-based systems, but several other manufacturers have also developed systems based on Itanium. As of 2007, Itanium is the fourth-most deployed microprocessor architecture for enterprise-class systems, behind x86-64, IBM POWER, and SPARC. Intel released its newest Itanium, codenamed Montvale, in November 2007.