Hustlin' is the first single off Miami rapper Rick Ross's debut album Port of Miami. There is a remix of this song that features Jay-Z and Young Jeezy. The song also appears remixed on DJ Drama & Lil Wayne's mixtape Dedication 2. An unofficial leaked remix was made featuring Lil Wayne, Z-Ro, Jay-Z, T.I., Busta Rhymes, Remy Ma, Young Jeezy & Lil Flip.

In the lyrics of the song, Rick Ross refers to the cocaine traffic network the real Rick Ross had built up, stating that he is "into distribution" like "Atlantic" and ships coc across the "Atlantic Ocean". The song also contains references to Manuel Noriega, former Panamanian Militant General, Pablo Escobar, Colombian narcotics trafficker, and Kenneth "Black" Williams, Miami-area drug runner. To emphasize that he is talking about Noriega the dictator and not Noreaga, the Queens-based rapper, Ross adds "the REAL Noriega", who he claims owes him "a hundred favors."

In the video, Rick Ross wears a shirt with the words Boobie Boys in homage to a drug gang. Pitbull, Trick Daddy, Cool and Dre, Smitty, DJ Drama, DJ Khaled, Field Mob, The Runners, and Trina are seen in the music video.