His Holiness is the official style or manner of address in reference to the leaders of certain religious groups. In the Catholic Church (including the Eastern Catholic Churches) the style is used when referring to the Pope.

In the Coptic Orthodox Church, it is used for the Pope of Alexandria. It is also used in reference to some other patriarchs in the Christian Orthodox Church. In Tibetan Buddhism, the Dalai Lama is also addressed in the same manner in English, as are other Buddhist leaders such as Sakya Trizin, the Patriarch of Sakyapa, the Dalai Lama and Karmapa.