Here We Go Again may refer to:

In film and television:

• Here We Go Again (TV series), a 1970s American sitcom starring Larry Hagman
• Here We Go Again (film), a 1942 film featuring Ginny Simms

In music:

Albums:

• Here We Go Again (SR-71 album), and the title song
• Here We Go Again (Baha Men album), by the Baha Men
• Here We Go Again, an EP by The Mighty Mighty Bosstones
• Here We Go Again, by Red Steagall
• Here We Go Again, the original title of Year of the Dog...Again by DMX

Songs:

• "Here We Go Again" (song), a song by Sara Paxton
• "Here We Go Again" (Ray Charles and Norah Jones song), from the Ray Charles album Genius Loves Company
• "Here We Go Again", by DMX from ...And Then There Was X
• "Here We Go Again", a song by Danger Mouse and Jemini from Ghetto Pop Life
• "Here We Go Again", a song by John Lennon from Menlove Ave.
• "Here We Go Again", a song by Paramore from All We Know Is Falling
• "Here We Go Again!", a song by Portrait from Portrait
• "Here We Go Again", a song by The Hives from Barely Legal and Your New Favourite Band

"Here We Go Again" is a song by Sara Paxton for her debut album entitled Here We Go Again.