Harriet Sansom Harris (born January 8, 1955), is an American actress born in Fort Worth, Texas.

Harris started acting as a youngster and attended New York's famed Juilliard School. After graduation from Juilliard's Drama Division, she joined John Houseman's touring repertory company The Acting Company, where she stayed for three years. During this time, she performed in productions of Shakespeare's King Lear and Romeo and Juliet, the classic Antigone, and alongside Frances Conroy in Bertolt Brecht's Mother Courage and Her Children.

Harris went on to do extensive work on and off-broadway including a 1989 performance at Second Stage Theatre in What a Man Weighs . One of Harris's breakthrough stage performance came in the original cast of Paul Rudnick's Jeffrey, where she was the sole female cast member. Her work in Jeffrey led to numerous television guest appearances, including a recurring role on the TV series Frasier as Frasier's conniving agent Bebe Glazer.

Harris had a recurring role on the hit comedy-drama Desperate Housewives as Felicia Tilman. Her own series (including The Five Mrs. Buchanans, Union Square, and It's All Relative) were unsuccessful, but her guest roles on hit series, including Ghost Whisperer, Murphy Brown, Ally McBeal, Six Feet Under, and Ellen were memorable. Among them was her performance on The X-Files as Dr. Sally Kendrick and her "Eve" clones, from which the band Eve 6 derived its name. She has more recently starred on the new Sci Fi Channel television miniseries The Lost Room as Margaret Milne.

Harris received a Tony Award in 2002 as a Featured Actress in a Musical for playing the evil white slaver Mrs. Meers in Thoroughly Modern Millie.

In 2006 she appeared as Vera Charles in the Kennedy Center's summer production of Mame opposite Christine Baranski in the title role. In early 2007, Harriet appeared as Amanda Wingfield in the production of The Glass Menagerie at the Guthrie Theater. In the summer of 2007, Harriet appeared on Broadway in the revival of the John Van Druten comedy Old Acquaintance as Mildred Watson Drake with Margaret Colin at the American Airlines Theatre.

In 2007, Harris joined the cast of the new musical Cry-Baby, based on the John Waters film of the same name. It has been announced that the production is being transfered to Broadway's Marquis Theatre, with previews beginning on March 15, 2008, and the opening on April 24.

Born in Texas, Harriet Sansom Harris got involved in acting as a youngster. At seventeen, Harris was accepted at New York's famed Juilliard School. Upon graduation, Harris joined The Acting Company, a repertory group formed by the first alumni of John Houseman's Drama Division of The Juilliard School. She spent three years with the Company before she left to work primarily in regional theater. This led to a successful Broadway and Off-Broadway career. Her life changed after appearing as the sole female in the original cast of "Jeffrey", Paul Rudnik's smash Off-Broadway hit about love in the time of AIDS. "Jeffrey" led to guest shots on series television, including "Frasier" (1993), where she created the memorable role of Bebe Glazer, Frasier's cutthroat, neurotic, chain-smoking agent. She also won raves from critics for her role of Vivian Buchanan on CBS's "The Five Mrs. Buchanans." She now calls New York her home, but frequently travels to California for film and television appearances.