Hannibal Lecter is a fictional character in a series of novels by author Thomas Harris. Lecter is introduced in the thriller novel Red Dragon as a brilliant psychiatrist and cannibalistic serial killer. This novel and its sequel, The Silence of the Lambs, feature Lecter as one of two primary antagonists. In the third novel, Hannibal, Lecter becomes the main character. His role as protagonist continues into the fourth novel, Hannibal Rising, which explores his childhood and development into a serial killer. Lecter's character also appears in all five film adaptations. The first movie, Manhunter, was loosely based on Red Dragon, and features Brian Cox as Lecter, inexplicably spelled as "Lecktor". In 2002, a second adaptation of Red Dragon was made under the original title, featuring Anthony Hopkins, who had previously played Lecter in the motion pictures The Silence of the Lambs and Hannibal. Hopkins won an Academy Award for his performance of the character in The Silence of the Lambs in 1991.

In 2001, Hannibal Lecter (as portrayed by Hopkins) was voted by The American Film Institute to be the most memorable villain in film history.