Greenwood is a city in and the county seat of Leflore County, Mississippi, United States, located at the eastern edge of the Mississippi Delta approximately 96 miles north of Jackson, Mississippi and 130 miles south of Memphis, Tennessee. The population was 18,425 at the 2000 census. It is the principal city of the Greenwood, Mississippi Micropolitan Statistical Area. The Tallahatchie River and the Yalobusha River meet at Greenwood to form the Yazoo River.