In the episode with the dune buggy, when Drake and Josh are watching TV, you can hear an old sketch from "Amanda Show, The" (1999) in the background. Both stars appeared on "Amanda Show, The" (1999) before moving on to this show.

In some exterior shots of the cinema Josh works at, there is a shot next door with the name "Schneider's Bakery", the name of Dan Schneider (II)'s production company.

In the 2nd season episode "Dr. Drake", the name of the hospital is "St. Schneider's". Dan Schneider is the producer of the show.

Drake's main guitar is a J.B.P. stratocaster look-alike

In the episode with the spring break students partying at Drake and Josh's house, the hotel that their parents stay in is called "The Four Schneiders", a reference to the producer of the show, Dan Schneider