"Don't Let Go (Love)" is the first single from musical group En Vogue's third studio album, EV3. It has been certified platinum by the RIAA for shipments of over 1,000,000 units. The song was the last single by En Vogue to feature former band member Dawn Robinson. The song became En Vogue's biggest international single, peaking in the top ten of many countries. It hit #5 in the UK in early 1997 and spent a formidable sixteen weeks in the UK top forty, nine of those weeks in the top ten. It reached #2 on the U.S. Billboard Hot 100 (becoming their third #2 hit on the chart). The song was a #1 R&B song for 1 week becoming En Vogue's sixth and final #1 R&B Hit to date. The song was notable in the 1996 movie Set It Off.

This song compelled Elektra mogul Sylvia Rhone to place En Vogue back in the studio to record their EV3 for release in 1997. However, Dawn felt her solo career and membership in En Vogue were plausible while other members, producers, and executives wanted full dedication to the new album. Forced to chose, Dawn decided to leave En Vogue for a solo career with Dr. Dre's Aftermath Records. The turn of events following the success of Don't Let Go (Love) was the beginning of a long and tumultuous era for En Vogue as member changes became quite frequent.

During promotion of the single, several versions surfaced. The main album version was essentially used for the music video, but with a slightly different ending where Terry Ellis ad libs as the final chorus fades. An edit version which cut out several seconds in the beginning, as well as the instrumental following Cindy's ad libbing towards the end, was mainly spun at radio stations.