"Disease" is the first single from Matchbox Twenty's third album, More Than You Think You Are. It was co-written by Matchbox Twenty lead singer Rob Thomas and The Rolling Stones frontman Mick Jagger. It had some success on rock and alternative charts, though—owing to its relatively hard rock sound—it was not as successful on mainstream pop charts as some of Matchbox Twenty's other singles (peaking at #29 on the Billboard Hot 100).