Desilu Productions was a Los Angeles, California based company jointly owned by American actors Lucille Ball and Desi Arnaz. The name is a portmanteau of their first names. The studio was named after Arnaz and Ball's ranch in Chatsworth, California, located about 25 miles northwest of Hollywood in the San Fernando Valley.

Desilu Studios was home to I Love Lucy, and additionally, such hit television series as Star Trek, The Andy Griffith Show, Mission: Impossible, The Untouchables, Mannix, The Lucy Show, I Spy and Hogan's Heroes.

Its successors were Paramount Television and Lucille Ball Productions.