Def Jam: Fight for NY is the sequel to Def Jam Vendetta, a hip hop-influenced 3D fighting game released for the PlayStation 2, Xbox, and GameCube. The game features several rappers, including Method Man, Snoop Dogg, and Busta Rhymes, as well as the voices and likeness of other actors and celebrities, among them actors Omar Epps and Danny Trejo, punk rocker Henry Rollins, Carmen Electra, and Kimora Lee Simmons.

The game was spun-off into a 2006 PlayStation Portable game called Def Jam Fight for NY: The Takeover.